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Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this Article

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It is typically supplied as a white to off-white lyophilized powder for reconstitution into assay-appropriate solutions

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For patients with severe deficiency or conditions such as pernicious anemia, our team may recommend an initial loading phase, which often involves administering 1000 mcg of B12 intramuscularly or subcutaneously daily or every other day for one to two weeks