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As a result, oxyThDP inhibits ThDP-dependent dehydrogenases, whose function is required for ACh synthesis, particularly pyruvate dehydrogenase complex generating ACh precursor acetyl-CoA (Figure 1)

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10.1039/C8TB00022K 90 WuY.ZhangR.TranH

We applied five genetic causal inference methods: inverse variance weighted (IVW), MR-Egger, weighted median, weighted mode, and simple mode