It bypasses the normal feedback loops that regulate IGF-1 production, including GH negative feedback on the pituitary
The severity and the reversibility of drug-induced ototoxicity depend on factors, such as dosage, duration of exposure, patient susceptibility, and concurrent use of other ototoxic agents (Steyger 2021b
10.1016/j.exppara.2025.108942 7 BergM.Garca-HernndezR.CuypersB.VanaerschotM.ManzanoJ
Ethics declarations Ethics approval and consent to participate All animal procedures were approved by the Institutional Animal Care and Use Committee (IACUC) of the Fourth Affiliated Hospital of Harbin Medical University (No.:2025-DWSYLLCZ-76)
As the nanoparticles degraded, they released proteins into the saline solution
Yen & Jaffes Reproductive Endocrinology: Physiology , Pathophysiology , and Clinical Management , Seventh Edition