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On 29 January 2026, the MHRA updated product information for GLP-1s and issued a drug safety alert to highlight that acute pancreatitis is a known but infrequent side effect that can be fatal, stressing that patients and clinicians should be alert to initial symptoms, such as severe, persistent stomach pain that may radiate to the back and may be accompanied by nausea and vomiting 26

Nausea is the dominant early symptom, often described as a mild queasiness that peaks in the morning or after eating

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References Gopinath D, Koe KH, Maharajan MK, Panda S

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