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Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurological disorder characterized by muscle paralysis caused by the degeneration of motor neurons in the brain, brainstem and spinal cord
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Moreover, the combined blockade of VEGF and ICT is also correlated with adverse effects, including an increased risk of cardiovascular disease, highlighting the need for alternative therapeutic targets (265, 266)
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