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We also found that the DNA damage marker -H2AX was reduced

Estimated change in mean (s.d.) percentage weight loss from baseline to week 68 was 18.0 (9.2) with semaglutide 2.4 mg ( n = 34) versus +0.4 (7.0) with placebo ( n = 29)

This decline coincides with reduced healing capacity, slower tissue regeneration, and accelerated aging

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However, the effectiveness of Tirzepatide may be impacted by the involvement of the digestive tract