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This protein transports the heme precursor porphyrin [93], however the mechanism of transport has been shown to be GSH-dependent, with significantly increased activity in the presence of GSH [78]

Immune dysfunction and hyperglycemia Diabetic ulcers are a common and serious complication of diabetes, particularly in individuals with poorly controlled blood glucose levels

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Interestingly, His1-Gly2 of exendin-4 exhibited weaker density relative to the rest of the peptide in the cryo-EM map, and this is consistent with the enhanced flexibility observed for this region of the bound peptide in the simulations, likely due to Gly2, as glycine can destabilise -helical conformations

[6] [7] In silico modelling suggest that it has effects on thyroid hormone receptors