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Epub 2006 Aug 9
Once the amino acid sequence of the GLP-1 receptor was determined, the gene that codes for this protein was identified and human cells were engineered to include the gene
Injectable GLP-1 drugs like Ozempic were originally created to treat diabetes, but theyre now becoming famous for being a celebrity weight loss drug causing a shortage for patients who actually need it to treat their medical conditions
Dundar HA, Kiray M, Kir M, Kolatan E, Bagriyanik A, Altun Z, et al
For those on TRT or corticosteroids, the drug is unlikely to reduce the need for replacement, but body composition and metabolic shifts may change dose requirements or symptom perception
It is important to note that modifications in IGF-1 LR3 contribute to its low affinity to insulin-like growth factor binding proteins (IGFBP), extending its half-life
