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The insidious part of underdosing is that it looks like treatment failure
Cholesterol efflux has long been regarded as a critical mechanism of maintaining intracellular cholesterol homeostasis, which could be primarily regulated by the LXR transcription factors and their targeted genes, the ATP-binding cassette (ABC) cholesterol transporters ABCA1 and ABCG1 (Robichaud and Ouimet, 2019)
Obesity Reviews, 26 (8), e13929
Notably, both agents produced significant reductions in depression and asthma prevalence, accompanied by decreased antidepressant and asthma medication usage ( Tables S14S17 ), suggesting clinically meaningful improvement in symptomatic disease burden
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