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The timing of symptoms is diagnostically important
Moreover, the efficacy of these drugs in MC4R KO mice aligns with clinical studies, indicating that MC4R KO mice serve as a reliable animal model for obesity research
Another control-HGF group ( light-blue bars 5 , receiving a solvent followed by the wash-out step) also displayed a low activation index comparable to the level of the control HGF ( gray bars 3 ), indicating again that the solvent of LASSS is not involved in the mechanism that elevates c-met binding, as shown in Figure 1e, right column