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However, the low half-life of GLP-1 incretin could affect this process in individuals with DM2 or obesity (32, 33)

N Engl J Med 389:514526 Eli Lilly and Company (2023) A randomized, double-blind, phase 3 study to investigate the efficacy and safety of LY3437943 once weekly compared to placebo in participants with severe obesity and established cardiovascular disease

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PMID: 39790582

Both mGlp-1r and hGLP-1R mice treated with EX-4 displayed approximately 50% decrease in gastric emptying compared to vehicle-treated animals (PBS) ( Figure 3E )

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