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However, through several magnetic resonance spectroscopy studies (MRS) it has been shown that GSH levels are significantly decreased in the hippocampus, frontal, and cingulate cortices early in AD progression (Mandal et al., 2022)

However, despite its promising therapeutic effects, the use of HGF protein is limited by its poor bioavailability

2018;174:9991014.e22

This means the compound accumulates to steady-state concentrations over several weeks of daily dosing

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