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My experience made me wonder what proactive steps people with diabetes can take when they have to come off a GLP-1 drug even temporarily because of cost, side effects , or other reasons
a history of severe hypoglycemia and/or hypoglycemia unawareness, as well as recent hypoglycemia, prior exercise, and sleep
Switching to an oral pill may appeal to those who dislike injections or want a simpler dosing routine, while a lower injectable dose may offer a cheaper option that may also result in less adverse events
Retrieved 15 February 2026
Participants taking the highest dose of orforglipron (36 mg) experienced a mean weight loss of 7.3 kg , or 7.9%, compared with 1.3 kg or 1.6% in the placebo group
Understanding what to anticipate once the goal weight is achieved assists individuals in consulting with their physicians and preparing for optimal outcomes
