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Efficacy of Weight-loss A recent systematic review and a meta-analysis by Wong et al (2025) found that GLP-1 receptor agonists induced an additional 4.45 kilogram of weight loss over placebo based on 47 randomized control trials with a cohort of 23,244 patients
But it lacks the thorough Phase III trial data required for FDA approval
& Matarrese, P
Low protein intake on GLP-1 medications causes muscle loss, which worsens fatigue
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