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These include the catabolism of tyrosine, the synthesis of epinephrine from tyrosine (critical enzyme is dopamine -hydroxylase), the synthesis of carnitine, peptide hormone amidation, and the synthesis of bile acids

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A phase 2, adaptive randomized, double-blind, placebo-controlled, multicenter, 52-week study of HM15211 in patients with biopsy-confirmed non-alcoholic steatohepatitis - Study design and rationale of HM-TRIA-201 study