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Some patients may need temporary reductions in their existing blood pressure medication doses as weight loss progressesa change only your physician should make

A 2025 meta-analysis found that semaglutide increased the relative risk of cholelithiasis (gallstones) by 1.92 , liraglutide by 1.75 , and tirzepatide by 1.36

In both these instances, conditions tend to improve due to body weight dropping making it important to recognise which benefits are due to weight loss rather than any specific pharmacological action

You may need a higher dose or you may need to take it longer before feeling differently

If any of these symptoms appear, it is important to consult a healthcare provider immediately

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