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Rate of homologous desensitization and internalization of the GLP-1 receptor

This reinforces the need for carefully titrated regimens, especially in clinical settings where circadian timing (chronopharmacology) may dictate efficacy

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10.1016/S0140-6736(80)91773-0 Khoo SH, Leyland MJ: Cerebral edema following acute sodium valproate overdose

1 Many of the cognitive and behavioral features of ASD are believed to arise from central nervous system dysfunction, but abnormalities in many non-central nervous system tissues have been associated with ASD