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Description

To assess whether circulating GLP-1 has access to the OB, we administered LUXendin 645, a fluorescent GLP-1R antagonist based on Ex9 19 , intraperitoneally (IP)

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Slowly depress the plunger to expel any air without wasting solvent

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SUPPORTS APPETITE AND METABOLIC FUNCTION Tirzepatide activates both GLP-1 and GIP receptors

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It may aid GLP-1 function somewhat, but effects are indirect and not comparable to GLP-1 receptor agonists

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