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It is reported from several authors that zinc sulphate supplementation has a positive effect in increasing zinc serum levels and thymulin plasma levels ( in vitro response to mitogens ( It has been shown that zinc supplementation enables DNA repair in lymphocytes of people with trisomy 21 ( It is relevant to report that zinc sulphate treatment seems to induce a clonal selection of immature and ineffective peripheral myeloid cells by a zinc-induced cell death mechanism ( The aim of our work is to confirm literature data on zinc levels in subjects with T21 in our T21 cohort compared to a control group in a larger cohort of subjects with trisomy 21, then to understand if there is a linear correlation between zinc levels and immune cell levels and finally to search if there is any difference in gene expression in lymphoblastoid cells, thymus and white blood cells from subjects with trisomy 21 and control group subjects

Composed of three crucial amino acids Glutamic acid, Cysteine, and Glycine this peptide plays a vital role in supporting muscle health and combating the damaging effects of free radicals

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Translational potential : Preclinical and early clinical evidence supports feasibility, safety, and efficacy in organ sparing and tumor response

doi:10.2174/138920011796504536