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PMID: 27517151 Citations are provided for research reference

Besides diabetes and high blood pressure, the following additional health conditions may also contribute to CKD 1 : Cardiovascular disease Systemic or kidney infections Immune system conditions (eg, lupus) Inflammation of the glomeruli (tiny filters) in the kidneys Inherited kidney disease (eg, polycystic kidney disease) Congenital defects (eg, kidney malformation, urinary tract obstruction) Medications and toxins (eg, prolonged medication, chemical, or street drug exposure) Factors such as those described above and various others can contribute to the decline in kidney function characteristic of CKD

The key is to recognize that most of the human evidence behind these compounds is limited, and a meaningful share of what circulates online is anecdotal, not clinical

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The authors concluded in the abstract that IAPP toxic oligomers are formed intracellularly within the secretory pathway in T2DM