Milovanovic M, Grujicic R
Or is hyperglycemia the consequence of oxidative stress
Importantly, such plasticity is tightly regulated by epigenetic remodeling, metabolic adaptation, stress-response programs, and microenvironmental cues, highlighting the dynamic and reversible nature of resistance
Why this trial matters: First bispecific + CD38 combo to show superior PFS and OS in Phase III in RRMM Potential new standard of care as early as second-line Demonstrates deep responses, high MRD-negativity, and durable outcomes First-line Strategies in BRAF V600E-Mutant mCRC: Real-World Evidence Signals Treatment Priorities In a real-world retrospective cohort of patients with BRAF V600E-mutant metastatic colorectal cancer (mCRC), frontline chemotherapy plus anti-VEGF therapy was associated with the longest survival outcomes, while BRAF-targeted strategies showed promising response rates, emphasizing the need for tailored therapy and prospective validation
Liang, H
Whether these materialize depends on funding and regulatory willingness to allow investigational use