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DPP4i inhibit oxidative stress via controlling glucotoxicity and lipotoxicity Studies showed that many gliptins significantly decreased ROS, RNS, DNA fragmentation, AGEs, and Nox4 and increased antioxidants in most of animal models of CV disease

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Excessive ROS damage oocyte DNA, impair mitochondrial function, and drive granulosa cell apoptosis, hallmarks of accelerated ovarian aging (Camerano Spelta Rapini et al., 2024

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