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Insulin resistance, a pathology closely associated with obesity, sarcopenia, and chronic low-grade inflammation -including age-related inflammaging- represents another key target of GLP-1RA actions

The most common cardiovascular (CV) manifestations in patients with type 2 diabetes are heart failure (HF), stable angina, nonfatal myocardial infarction (MI), peripheral arterial disease and ischemic stroke [2,3,4] which accounts for 60% of their deaths [5]

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[7] Bone mineral content in rats: A separate 12-week study reported increases in bone mineral content and bone size in young adult female rats