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A small subset of people may not lose significant weight at all on GLP-1s, which is a different issue from plateauing after initial loss

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Ipamorelin's durable contribution, as recognized in the primary literature, is its demonstration that GHS-R1a agonism could be pharmacologically dissociated from co-stimulation of the hypothalamic-pituitary-adrenal axis, evidence of signal diversity at the receptor that informed subsequent compound design

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