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Due to their weekly dosing schedule and greater mean weight loss seen in trials (15% for semaglutide and 21% for tirzepatide, compared to 8% with liraglutide), semaglutide and tirzepatide are more frequently prescribed than liraglutide for treatment of obesity [33,34,35]

Diabetes 63:37113720 Finan B, Ma T, Ottaway N et al (2013) Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans

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Their gut barrier is compromised