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However, mAb treatment tended to oppose age-related changes in 30 of these metabolites (22 marginally significant after FDR correction), including a reduction in the age-related rise of many glycerophospholipids, and a distinct clustering of metabolites from heart tissue in Old Con versus Old mAb-treated animals by PCA (Supplementary Fig

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In previous clinical trials, since depression was not the primary prespecified outcome, most of them did not systematically track mood changes, which may lead to an underestimation of the real risk of adverse mental events during the clinical trial stage [28, 29]

Of all the organs, the skin is the one that most clearly (and visibly) shows the signs of aging

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