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A., Wassel, A., and Bixquert, M
doi: 10.1093/humupd/dmh032 132 CaratyASmithJTLometDBen SadSMorrisseyACognieJet al
Patients should budget for a minimum treatment duration of several months, as clinical trials demonstrate that semaglutide's weight loss effects are most pronounced with sustained use over 1216 months
Gut microbiota metabolites and risk of major adverse cardiovascular disease events and death: a systematic review and meta-analysis of prospective studies
Safety signals identified through extended follow-up include: Gastrointestinal effects : Nausea, vomiting, and diarrhea remain the most common adverse events, typically diminishing over time but causing discontinuation in approximately 57% of patients Gallbladder disease : Increased incidence of cholelithiasis and cholecystitis, possibly associated with weight loss, though the exact mechanism remains under investigation Diabetic retinopathy : Risk of complications, particularly with rapid glycemic improvement in patients with pre-existing retinopathy Acute kidney injury : Risk associated with severe gastrointestinal adverse events leading to dehydration Pancreatitis : Rare cases reported, though causality remains uncertain
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