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There are currently four approved SGLT-2 inhibitors (canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin) that have been approved by the FDA for their use in adults

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2015 examined obese male mice on a high-fat diet and reported that while the HFD mice had lower serum testosterone (which exenatide treatment did not fully restore), the GLP-1 RAtreated mice did show improved sperm motility, enhanced sperm mitochondrial activity, and reduced sperm DNA fragmentation compared to untreated obese controls