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Trials like SARC045 are assessing pembrolizumab in sarcoma subtypes, including MPNST, particularly in tumors with mismatch repair deficiency or high tumor mutational burden
Netea MG, Quintin J, van der Meer JW
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This concept eventually led to drugs like sitagliptin (approved 2006), but those would generally have less potent effects than direct GLP-1 agonists since GLP-1 levels only double or triple on DPP-4 inhibitors (and those drugs rely on some residual pancreatic function and meal stimulation) ( [59] )
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