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On December 5, 2017, the FDA approved Ozempic (semaglutide) for type 2 diabetes

Retatrutide monotherapy achieved 24.2% weight reduction in phase 2 trials, while cagrilintide combined with semaglutide (CagriSema) reached 22.7%

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3.2 Lactic acidosis During metformin treatment, plasma lactate concentration increases with enhanced glucose uptake in the intestine, resulting in side effects in some patients with one or more risk factors for lactic acidosis (Bailey et al., 1992

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