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Changes in MtDNA copy number in senescent oocytes The prevalence of infertility, spontaneous abortion, and congenital disabilities has increased in recent years with increasing reproductive age in women, and the core pathologic basis of these reproductive outcomes lies in the decline in developmental potential triggered by damage to the quality of oocytes [46, 47]

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Broadly, studies suggest GLP-1RAs exert their neuroprotective effects in the retina by mediating reduced glutamate excitotoxicity, decreased neuroinflammation, prevention of retinal ganglion cell (RGC) loss, promotion of vascular integrity, promotion of an anti-oxidative environment, and maintenance of glial cells (i.e

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(PubMed) Fenwick GR, Heaney RK, Mullin WJ