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Answer: The gut hosts a large share of the body's immune tissue, so when the intestinal barrier is compromised the resulting inflammation can show up far from the digestive tract, in joints, skin, energy, and cognition

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10.1074/jbc.M101355200 J

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The axis of miR-30a/AIF-1/TRPC6/calcineurin A/NFAT2 regulated the death modalities and inflammation of renal tubular epithelial cells in diabetic kidney disease via exosome