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Beyond this BMI range, however, it becomes increasingly unlikely that patients will achieve the level of weight loss necessary for the health outcomes they and their care team hope for with the medication alone

The impact of GLP-1 receptor agonist liraglutide on blood pressure profile, hydration, natriuresis in diabetic patients with severely impaired kidney function

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Annals of Neurology, 36(3), 356-361

However, it is generally used in cycled protocols (e.g., 8-16 weeks) rather than continuous long-term therapy