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Heritability estimates for BMI range from 40 to 70%

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Cardiovascular effects of different GLP-1 receptor agonists in patients with type 2 diabetes

Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]