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Elife 5 , e11288, (2016)
Tennessee braces for rising costs of GLP-1 drugs amid increased demand, uses Tennessee's Medicaid program, TennCare, covers drugs like Ozempic and Mounjaro to treat those with diabetes and heart conditions
It tells the pituitary gland to release more GH, which in turn tells the liver to make more insulin-like growth factor 1 (IGF-1) the hormone that drives a lot of GH's downstream effects on tissue growth, fat metabolism and repair
Built for Higher Stability: Cyclization (AspLys lactam bridge) plus amino-acid substitutions (e.g., Nle , D-Phe ) help reduce enzymatic breakdown in experimental systems
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