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This temporal data underpins the research design rationale for PEG-MGFs extended half-life: it must be present during the acute 024-hour MGF signalling window and maintained through the proliferative phase

In our cohort, visual impairment at baseline was seen in 21 (53.8%) patients and remained the only predictive factor of visual impairment but not visual worsening at M6

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Hepatocellular granularity may be due to swelling of cell organelles or increase in the numbers of cell organelles including peroxisomes, mitochondria, and smooth endoplasmic reticulum

And this point is relevant as TMAO is excreted by the kidneys, and so damaged kidneys cannot excrete TMAO effectively