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Tirzepatide (Mounjaro/Zepbound), also made by Eli Lilly, is a dual GLP-1/GIP agonist
Just a year and a half ago, Elizabeth Ellison-Brown began injecting semaglutide intermittently
Each time you withdraw a dose, use a new sterile needle to minimize contamination risk
JCI Insight 5(17):e140532 Killion EA, Wang J, Yie J, Shi SD, Bates D, Min X et al (2018) Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
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The appetite-suppressing effects might reduce binge eating but could also reinforce the food restriction that typically precedes binges and worsen the cycle overall ( Schaefer et al., Psychiatric Clinics of North America, 2026 )
The right choice depends on your medical history, how you tolerate each medication, your goals, and cost and availability
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