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The American Diabetes Association notes that GH excess (as seen in acromegaly) causes frank diabetes in approximately 20-30% of patients [11], a caution that extends by mechanism to prolonged secretagogue use
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When combined with insulin or sulfonylureas, the risk of Hypoglycemia increases, and a dose adjustment of the existing medications may be required
Among users who post about side effects, the most-discussed run nausea, fatigue, GI-other, anxiety, diarrhea, constipation, menstrual changes, and reflux/burps, in that order
Retatrutide safety and side effects The Phase 2 clinical trial results showed an incidence of adverse events in 70% of patients in the placebo group and 73 to 94% in the retatrutide group
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