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Furthermore, the clinical translation of LDHA inhibitors as a class has been challenging, often hampered by issues of toxicity and lack of selectivity [222]

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Besides that, caffeine can affect liver metabolism and potentially diminish the availability of glutathione (4)

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A phase 1b study is ongoing to evaluate the addition of tetrathiomolybdate to chemotherapy and immunotherapy in the adjuvant setting for high-risk triple-negative breast cancer (NCT06134375)