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Jos Esprito Santo, Lote 49, Loja 1, Chelas, 1900-672 LISBOA, PORTUGAL Telephone: + 351-218371699 Fax: + 351-218371712 E-mail: [email protected] Acknowledgements This article is based on a paper presented at the International Conference on Chromosome 21 and Medical Research on Down Syndrome, Barcelona, 1997

The neurological effects of viruses are associated with direct infections of structures of the CNS, the migration of infected leukocytes to the CNS, or/and the immune response to control the infection

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Thus it is not surprising that compounds that increase the activity of the P450 enzymes, such as caffeine[40, 41] and anticonvulsant drugs[42] also make APAP more hepatotoxic

Suzuki T, Heaney LM, Bhandari SS, Jones DJ, Ng LL