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This peroxidation occurs via two major pathways: the enzymatic pathway, mediated by lipoxygenases (LOXs), cytochrome P450 oxidoreductase (POR), and NADPH oxidases (NOXs), promotes the generation of PUFA-PL-OOHs, leading to the accumulation of reactive aldehydes, ketones, and other toxic metabolites, ultimately disrupting membrane integrity and triggering ferroptosis (Maheshwari, 2023)
doi: 10.3389/fimmu.2025.1482308 Received 18 August 2024 Accepted 02 January 2025 Published 21 January 2025 Volume 16 - 2025 Edited by Pengpeng Zhang, Nanjing Medical University, China Reviewed by Sangsu Bang, Duke University, United States Deron R
Oxygen Radicals in Biological Systems
Pharmaceuticals, 15 (9)
It has to be alerted to the presence of nutrients outside of the cell wall by a sensing mechanism so that a transporter protein can bring the nourishment inside
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