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2.5 Model Predictions Because of substantial log-normal within-individual variability, standard computation of reference subject simulations, as well as population predictions and weighted residuals reported by the nonlinear mixed-effects modelling software (NONMEM) are poor measures to reflect data

That said, the severity and pattern may differ

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PlexusDx's pricing remains flat regardless of dose escalation, meaning a patient reaching a higher therapeutic dose pays the same monthly fee as someone beginning treatment

For systemic treatments (like insulin or anti-inflammatory drugs), the drug is circulated throughout the body to exert its effect [77]