No adverse fetal effects have been documented from normal therapeutic doses of hydroxocobalamin in human pregnancies
While some people can obtain adequate B12 from a balanced diet, others may need injections, especially if they have absorption issues or dietary restrictions
These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance
PubMed ID: 11146367 Heffernan MA et al
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