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(4) The researchers reported, On days 6, 10, and 13, tripeptide-copper complex-treated wounds contained significantly lower concentrations of TNF-alpha and MMP-2 and MMP-9 than control wounds. Tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in systemic inflammation, along with matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) enzymes that break down extracellular matrix proteins might potentially influence both the inflammatory processes and the remodeling of tissues

All three components appear in the literature in overlapping tissue-repair contexts, and all three are proposed to act by mechanisms that do not obviously collide

Digestive side effects: 17% reported mild bloating and irregular bowel movements that resolved after stopping the drink

doi: 10.1038/srep45980 75 ChicoVNombelaIPuente-MarnSOrtega-VillaizanM

Inflamed synovium produces prostaglandins, leukotrienes, ROS, cytokines, chemokines, and adipokines, all of which contribute to cartilage breakdown and further exacerbate inflammation (Scanzello and Goldring, 2012)

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