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Some patients do not experience fatigue at all, while others notice tiredness during the early adjustment period

Daidone says

Key Mechanisms of DDIs 1 Metabolic DDIs (CYP450) Inhibition increased exposure & toxicity Induction reduced exposure & loss of efficacy Example: CYP3A inhibitors increasing statin levels myopathy risk

10.3389/fnut.2022.948573 46 MarinhoT

Novo Nordisk filed for FDA approval of CagriSema (the cagrilintide plus semaglutide combination) in late 2025, but the standalone compound has not been submitted for approval

From a more general point of view, it is particularly interesting that these drugs exert their therapeutic action by acting on the brain to reduce appetite and thus create a significant caloric deficit