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NH residents weighing this trade-off should also note that the boxed warning for thyroid C-cell tumors applies to both semaglutide and tirzepatide based on rodent studies, regardless of whether the formulation is branded or compounded

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However, patients taking tirzepatide, particularly those new to the medication or experiencing gastrointestinal side effects, may benefit from more conservative limits or temporary abstinence during dose titration periods when side effects are typically most pronounced