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Risk factors for NAION: Age (usually affects people over 50) Diabetes Hypertension High cholesterol Sleep apnea Anatomical predispositions (such as a small cup-to-disc ratio) Symptoms of NAION include sudden vision loss in one eye (ranging from mild to severe), missing portions of vision (visual field defects), and disc swelling

Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1

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Deficiencies in carnitine or its transporters have been linked to low sperm motility, reduced sperm quality, and suboptimal fertility outcomes