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Toxicity: Preclinical trials indicate no observable adverse effects on hepatic, renal, or cardiovascular systems at standard research dosages (5 mg/kg - 20 mg/kg in murine models)

Those with deficiencies may need up to 1,000 mcg daily until levels normalise, then maintenance doses of 25-100 mcg

doi: 10.1186/s12935-018-0504-4 92 KippAP

Self-administered B12 shots are generally recommended for individuals: whose bloodwork has documented low B12 levels Patients with pernicious anemia or a lack of intrinsic factor Individuals with Crohn's disease, celiac disease, or post-bariatric surgery malabsorption Vegans and strict vegetarians are unable to correct the deficiency through diet Older adults whose stomach acid production has declined with age Anyone on long-term metformin or proton pump inhibitors Across most of the U.S., injectable B12 is not sold over the counter a clinician has to write the script before a pharmacy can dispense it

publicly stated during a Joe Rogan podcast appearance and reiterated in follow-up HHS communications that the FDA would return 14 of 19 previously Category 2 peptides to Category 1 compounding status

anti-GCLM (rabbit, 1:2000, Proteintech)