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Many people feel energized quickly, while others notice benefits gradually over the next hours or days

Joint Discomfort or Tingling: Occasional joint stiffness or tingling may occur as GH and IGF-1 levels rise usually short-lived

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During the transition period, supplemental digestive enzymes may be beneficial to avoid gastrointestinal upset

5 Challenges and future directions in microbiota-based interventions for hypothyroidism Although microbiota-targeted strategies present a promising adjunct in the management of hypothyroidism, several critical challenges must be addressed to fully realize their therapeutic potential (Figure 5)

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