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The clinical trial evidence on duration The landmark STEP trials for semaglutide and SURMOUNT trials for tirzepatide provide the clearest data on what happens at different treatment durations

This modification uniquely induces structural rearrangements associated with amyloidogenic conversion, in contrast to other post-translational modifications on Cys10, such as, S-cysteinylation or S-glutathionylation, that do not significantly alter the native fold [22]

M.ParradoC.Santos-GonzalezM.AlcainF

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